| ●Preface ［Japanese］ & ［English］ | 1-11 | |
| ●Round table discussion | ||
| Application of Statistical Principles for Clinical Trials | Hirotsu C，Kurihara M， Shimizu N，et al． | 13-66 |
| ●Commentary | ||
| Concluding Remarks on the Round Table Discussion on “Application of Statistical Principles for Clinical Trials” with Some Related Statistical Comments | Hirotsu C | 67-71 |
| Statistical Principles for Coming Clinical Trials | Sato T | 73-81 |
| ●Original | ||
| Roles and Significance of the Subjective Global Judgements by Investigators in Confirmatory Climcal Trials | Tsubaki H，Kurihara M | 83-99 |
| Phase I Study of Quetiapine Fumarate (ICI 204, 636, Zeneca) on Healthy Male Volunteer |
Murasaki M，Shimada E， Yoshimoto S，et al． | 101-44 |
| ●Report | ||
| Production and Distribution of Japanese Randomized Controlled Trials Papers |
Yamazaki S | 145-53 |
| ●News | ||
| The citation of randomized controlled trials (RCT) published on Rinsho Hyoka (Clinical Evaluation) have been included in The Cochrane Library 1999 Issue 3 |
155-6 | |
| Medline's Journal Review Summary | 157-8 | |
| ●Materials | ||
| Statistical Principles for Clinical Trial ［Japanese］ & ［English］ | 159-241 | |
| ●Notice to authors ［English］ | 245-7 | |
| ●Editor's note | 249 | |